LATAM Ecuador serves the following destinations:
| Country | City | Airport | Notes | Refs |
|---|---|---|---|---|
| Buenos Aires | Ministro Pistarini International Airport | Via Lima | [1] | |
| Santiago | Arturo Merino Benítez International Airport | |||
| Bogotá | El Dorado International Airport | [2] | ||
| Baltra Island | Seymour Airport | |||
| Cuenca | Mariscal Lamar Airport | |||
| Guayaquil | Jose Joaquin de Olmedo International Airport | Hub | ||
| Loja | Ciudad de Catamayo Airport | |||
| Manta | Eloy Alfaro International Airport | |||
| Puerto Francisco de Orellana | Francisco de Orellana Airport | |||
| Quito | Mariscal Sucre International Airport | Hub | ||
| San Cristóbal Island | San Cristóbal Airport | |||
| Santa Rosa | Santa Rosa International Airport | |||
| Lima | Jorge Chávez International Airport | Operated by LATAM Perú | ||
| Madrid | Adolfo Suárez Madrid–Barajas Airport | Terminated | [3] | |
| Miami | Miami International Airport | [4] | ||
| New York City | John F. Kennedy International Airport | Suspended | ||